Had these bags:
Crumpler 5 Million Dollar Home
Crumpler Karachi Outpost (S)
Have this bag:
Billingham Hadley Pro
So far I am the happiest with the Hadley Pro. Its shoulder strap is wide enough and the memory foam type shoulder pad really reduces the pressure on the shoulder. And it looks good, too!
IMHO: The Crumpler shoulder pad I bought for my 5MDH is too stiff for comfort, and ended up making the bag equally uncomfortable especially when I had to pack more than just a body and two lenses. The Karachi Outpost is practically useless for anything other than camera gear and laptop. When you remove the padded compartments, the empty space has no pocket whatsoever. Not ideal for travelling although its name suggests otherwise.