Based on my usage (I don't use tripod, camera is handheld using my body for support) on my D810, I set the following as baseline
"M" mode, Auto ISO with max of ISO6400, minimum of 800. 3D tracking in the center, VR on, AF-C, focus priority.
Then I will adjust aperture from f/6.3, 1/500 (dim, under shade conditions) to f/8,1/8000 (optimal, easy in outdoor area even in cloudy dreary weather) Thats around 5 stop range.
The trickiest part is getting AF to lock, the D810 3D AF works great in open areas.
The Tamron 150-600mm is optimal at f/8, given a choice I'll shoot at f/8 all the time. D810 handles up to ISO 6400 easily. Shutter speed I try to get 1/1000 at least.