Well, it is possible, look at those people in poorer countries, think they have no other choice.....
When I was working in the lab, we also put in many hrs, working through the night several times, all weekends we work in the lab (Sunday half day lah), but good thing was we had flexible hours, so we came to work around 11 am only, but stayed till 2-3 am.......
In those days, I hardly had time for holiday, I always accumulated my holidays till they expire
But we loved our work, so that's a blessing. In Singapore life is not that stressed, people here tend to think otherwise, but those are who have not seen life in HK, it is more stressful there! So, appreciate that it is not like there