Does this look better?
There is nothing wrong with the scanning software and the holders. Your image looks sharp and in focus to me. What you need to understand is the scanning process and workflow.
1. First of all, you need to know that scanners are dumb. There is no way that the scanner can scan and tell what colour is what and what is black and what is white. All the processing is done via software. If you never run the image through software or workflow, your images will basically look like uncooked meat... very raw and unprocessed. Even using the best negatives and slides, it will still not give you acceptable colours.
2. All negatives come with a certain colour tinge. Some are a little yellow, some red, some green and some purple. The scanner has no way to tell what tinge it is. Only we can tell. And it takes a trained eye to tell. That is why, there is something call profile. Vuescan and Silverfast have profiles that you can download or buy (I think) that can correct this tinge problem. I never bothered with all these. If you want to go to that detail, the best person to ask is Nero. I think he has experimented with quite a number of Silverfast profiles, and he can tell you what work best.
3. All I did was to use "Auto Colour" to correct the tinge problem. Most of the time it works well. It's like correcting the white-balance. After a while, you will know what kind of negatives produces what kind of tinge.
4. As for sharpness, please do not expect too much from a small piece of negatives. At 36mmx24mm, scanning at 2400dpi, do not compare with the 18 mega-pixel M9. First of all, ask yourself at what resolution you want to present your images. If you just want to show on iPad or flickr, scanning at 2400dpi is good enough. You can then sharpen your image using LR or Photoshop. There is no hard and fast rule or best software to do it. My rule is, as long as it looks nice, any software is good enough.
5. It's very hard to list down all the steps here. And there is no one step to achieve the desired result. It's like learning how to play guitar and piano. The best way to learn is to play & play & play, practice & practice & practice...
6. Just continue to shoot, process and tweak... There is no such thing as a "raw scan looks best". Any media converted from analog to digital, need to go through some form of manipulation. Same as converting analog LP to digital format, there needs to be some form of manipulation to "massage" sound to make it more pleasant.
Hope that helps....