No, noise reduction and sharpening are 'opponents' in post processing. Noise removal also reduces details in the image, because pixels and their information get changed. But in contrast to in-camera noise reduction, the software has much more options and allows much finer adjustments. It doesn't need to be PS and layering works. Adobe Lightroom (I'm just a user, no relation to the company, btw) is pretty good at that. Plus: there are tons of tutorials in the Internet. Of course, all these editing steps are most effective when using RAW images. Using JPG files, after in-camera processing there isn't much left that can be done at them.