depends on lighting condition and camera body, i feel no different with AF in the day time
even at night time, the slow down is negligble, at least it never hunt on my 1D
on the other hand, the Canon 2x TC slow down the AF so much and hunt until it cannot focus properly at night. On top of that, the image quality degrade significantly.
IMO, 2x TC is more suitable for fast L primes
for other lenses, better check if u can stack a TC on it because some of the lens got rear element so near to the opening that it will hint the TC